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Current cases

pract. med.
Alexander Meisel<
Medical Oncology
Kantonsspital Glarus
Burgstrasse 99
8750 Glarus

Case 61

Treating advanced prostate cancer in the elderly: a success story

History

March 2023

A retired lecturer in international affairs presents to his general practitioner with recurrent bone pain. He also reports that his longstanding lower urinary tract symptoms, despite having been very moderate in the past, have recently worsened. The 80-year-old patient is overall in good physical health. He still rides his bike regularly, visits his mountain hut and takes care of the large forest plot he owns. Recently, though, these activities have been somewhat impaired by his increasing pain.

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Dr. Emanuela Salati
Specialist in Medical Oncology and General Internal Medicine
Head of the Department of Oncology
Centre hospitalier de Rennaz
Route du Vieux-Séquoia 20
1847 Rennaz

Case 58

Muscle-invasive bladder cancer: a case with encouraging results

July 2025

A female architect sees her primary care physician for dysuria, pollakisuria and general malaise. The 50-year-old Swiss patient has a history of recurrent urinary tract infections. Apart from her current symptoms, she is in very good general condition.

Status at presentation

175 cm, 70,4 kg, BMI 23 kg/m², BP 119/76, pulse 72 bpm, no fever, bladder tender to palpation, no tenderness of the costovertebral angle.

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PD Dr. med.
Alex Friedlaender
Department of Oncology
Clinique Générale-Beaulieu/
Swiss Oncology Network
Chemin de Beau-Soleil 20
1206 Geneva

Case 56

Management of adverse events during first-line treatment of locally advanced or metastatic urothelial carcinoma with enfortumab vedotin and pembrolizumab

Introduction

Between 2017 and 2021, the incidence of urothelial carcinoma (ICD-10 C67) in Switzerland averaged approximately 1300 cases annually, of which just over 300 occurred in women.¹ The mean number of urothelial carcinoma-associated deaths was 586.¹ This corresponds to 15,6 and 4,2 new cases per 100’000 men and women, respectively, at a median age of 74,7 years (men) and 75,9 years (women).¹ For patients with locally advanced and/or metastatic urothelial carcinoma (la/mUC), first-line therapy with the combination of enfortumab vedotin (EV) plus pembrolizumab (PEM) has been indicated since September 2024.²

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